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IP Profile: A novel nanocavity sensor for ultrasensitive, label-free biomolecular detection

A unique nanostructure is being developed for multimodel, multiplex biological and chemical sensing.
Organization: Boston College, Massachusetts, US
Inventors: Dong Cai, Thomas Chiles, Krzysztok Kempa, Zhifeng Ren
Primary Market: Sensors
Technology Contact:  Catherine L. Ives, Boston College, Massachusetts, US

IP Overview Courtesy of C. Ives, Boston College, US

A unique nanostructured sensor is being developed for multimode, multiplexed biological and chemical sensing. The adjustable nanoscale size allows for superior signal-to-noise due to substantial perturbations in the sensor response, even by individual biological entities such as proteins, nucleic acids, viruses, etc. The sensor consists of an array of nanosensors each of which consists of two carbon nanotubes comprising an inner conductor and an outer conductor. Inside the nanocavity is an immobilized active sensing element that will bind to a target particle and is detected by a measured change in the electrical parameters of the nanosensor array. Molecular imprinting of proteins allows for protein detection in attomolar (10-18) concentrations without the use of antibodies.

The technology provides a superior alternative to current diagnostic/sensor systems in that it is capable of detecting, via label-free, non-optic methods, single molecules using low concentrations of material, and is rapid and inexpensive. There is no need to amplify target material. Patents are pending.

We are looking for collaborators in pharmaceutical quality control monitoring, environmental monitoring, and human and animal diagnostics to jointly develop this technology to suit particular market needs.

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