Papers:
Gold-based Nanostructures for Improved Cancer Therapeutics
The field of nanotechnology is currently undergoing explosive development on many fronts. The technology is expected to generate innovations and play a critical role in cancer therapeutics. Among other nanoparticle (NP) systems, there has been [...]
NAD-Nanoparticles for Therapy and Diagnosis of Alzheimer Disease
NAD project (large cooperative; 19 partners, funded by the E.C.) is aiming to the therapy and diagnosis, even combined, of Alzheimer Disease, by synthesis of multiple-functionalized nanoparticles, able to bind, detect and remove Abeta from [...]
A better biomaterial for bone regeneration: type II collagen
Type II collagen facilitates osteogenesis and suppresses adipogenesis simultaneously during early stage of MSC differentiation, mediated through the same signaling cascades. Type II collagen-coated plates enhanced BMSC mineralization better than did either non-coated or type [...]
Poly-Vinyl Pyrrolidone (PVP)-coated Silver (Ag) Nanoparticles (Ag-PVP): a Potential to Regulate Chlamydia trachomatis Inflammation
Chlamydia trachomatis is an important cause of sexually transmitted infection that can manifest itself as either acute cervicitis, pelvic inflammatory disease, and more commonly as a chronic asymptomatic infection. Previously we reported Ag-PVP (5-10 nm) [...]
‘Sink effect’ of dually-decorated nanoliposomes on Abeta clearance
Plaques containing beta-amyloid peptides are one of the hallmarks of Alzheimer’s disease (AD) and the reduction of Abeta is considered a primary therapeutic target. Recently, strategies have been employed to reduce Abeta brain levels and [...]
Nanoherbal antiseptic medicine/ bandage for effective and safe treatment of external wounds
Use of different antibiotics and bactericides in treatment of wounds has resulted in several side effects together with development of resistant bacterial strains. The need is to develop safe and new route for the treatment [...]
Application of superparamagnetic nanoparticles for magnetically guided release of anti-cancer drug: An Ivvivo study on Rats
By using appropriate magnetic parameters, 50-80% of the injected nanoparticles could be targeted, thus eliminating systemic distribution and subsequent toxicity of the entrapped agent. In this report we present data on the use of magnetic [...]
Reversing Coagulopathy and Internal Hemorrhage with Functionalized Nanoparticles
Kudela D., May-Masnou A., Smith S.A., Braun G., Pallaoro A., Chuong T., Morrissey J.H., Stucky G.D., University of Californi, Santa Barbara, US
Uncontrolled hemorrhage is a major cause of preventable death. Wound treatment focuses on using nanostructured oxide and clay-based materials to quicken clot formation. Internal injuries further complicate treatment due to inaccessibility. In response to severe [...]
Effects of ZnO nanoparticles and ZnCl2 solution on rat liver and kidney
Ben Rhouma K., Ben Slama I., Amara S., Rihane Ben Younes N., Mrad I., Omri K., El Ghoul J., El Mir L., El Ghoul J., El Mir L., Ben Rhouma K., Ben Slama I., Abdelmelek H., Sakly M., Faculty of Sciences, TN
Recent studies have shown that Zn2+ is released from the surface of ZnO NPs when they are suspended in an aqueous state.The aim of this study was to evaluate the effects of ZnO nanoparticles (ZnO-NPS) [...]
Noble metal nanoparticles for plasmonic photothermal therapy of atherosclerosis
Background: Our previous bench studies PLASMONICS and NANOM First-in-Man trial documented TAV reduction up to unprecedented 79.4 and 60.3 mm3 respectively with high level of safety and feasibility. Methods: The completed randomized two arm (1:1) [...]
Magnetic Targeting of Human Aortic Smooth Muscle Cells for Rapid Closure and Healing of Intracranial Aneurysm/Pseudoaneurysm
Arias S.L., Alucozai M., Pastrana F., Reece L.M., Kempaiaih R., Pavon J.J., Allain J.P., Purdue University, US
A novel approach is proposed in this study using a magnetic strategy to address the current disadvantages of detachable coils and stent grafts for aneurysm/pseudoaneurysm treatment. It consists of a patch facing the aneurysm neck [...]
Iron-sequestering molecules play a pivotal role in the mechanism of toxicity of SWNTs on fungal and bacterial cells
Chaves J.S., Chaves S.J., Zuniga P., Chaves J.S., Chaves S.J., Instituto Tecnologico de Costa Rica, CR
In this study we described that iron-sequestering molecules are responsible for the toxicity of iron containing SWNTs to microorganisms. After incubating different concentrations of functionalized SWNTs with bacteria and fungal cells, it was found that [...]
Pharmacokinetics and Safety Studies of Low Molecular Weight Heparin Nanoconjugates
Low molecular weight heparins (LMWHs) have received widespread acceptance as the first choice for initial prevention and treatment of venous thromboembolism via subcutaneous injection one to two times daily in the clinic. The need for [...]
Cationic polystyrene nanosphere induces autophagy through inhibition of Akt/mTOR and activation of AMPK signaling pathways in macrophage and epithelial cells
Nanoparticles have been used to produce a wide range of products. Those include applications in imaging and drug delivery in medicine. However, the possible adverse biological effects in human being remain unclear. Autophagy is an [...]
Effects of Titanium Dioxide Nanoparticles (TiO2) on Behavioral Parameters of Rats
Rihane Ben Younes N., Amara S., Mrad I., Omri K., El Ghoul J., El Mir L., El Ghoul J., El Mir L., Jeljeli M., Ben Rhouma K., Abdelmelek H., Sakly M., Faculty of Sciences, TN
Titanium dioxide nanoparticles (TiO2-NPs) have a wide range of applications in many fields. The effects of TiO2 NPs on the central nervous system are still unclear. The present study, we investigated the effects of sub-acute [...]
Isolation and Detection of Cancer Related DNA Nanoparticulate Biomarkers Directly from CLL Patient Blood “Rapid Sample to Sequence Diagnostics”
The analysis of cell free circulating (cfc) DNA biomarkers continues to become more widely used for cancer diagnostics and management. Cfc-DNA ranges from nucleosomes and high molecular weight DNA nanoparticulates to 100-200bp fragments. We have [...]
Bio-imaging of colorectal cancer models using a CK19-bioconjugated Quantum Dot Nanoprobe
Gazouli M., Nikiteas N., Anagnou NP., Kelekis N., Efstathopoulos E., School of Medicine University of Athens, GR
The aim of the study was to develop and validate a QD-nanoprobe for the detection of CK19 protein for in vivo colorectal cancer molecular targeting. QDs with a maximum emission wavelength of 655 nm, were [...]
Metastatic diagnosis of colon cancer by vertically aligned carbon nanotube based electromechanical biosensor
Abdolahad M., Taghinejad H., Taghinejad M., Taghinejad H., Taghinejad M., Janmaleki M., Mohajerzadeh S., University of Tehran, IR
vertically aligned carbon nanotube based electrical biosensor was demonstrated as a more rapid, sensitive and specific device for metastatic diagnosis of colon cancer cells based on the mechanical entrapment of metastatic cancer cells on vertically [...]
Highly sensitive detection of cancer biomarker EGFR by PicoTREC-SERS
It is reported that for women in the U.S., breast cancer death rates are higher than those for any other cancer, besides lung cancer. Considering the fact that approximately 70–80% of breast carcinomas overexpress the [...]
Superparamagnetic Iron Oxide Nanoparticles as Drug Delivery Vehicles
In recent years, nanotechnology has emerged as one of the most promising fields for biomedical applications and healthcare. The use of nanoparticles has earned much attention due to their small size, high surface area to [...]
Lipopolymeric nanoparticles: platform technology for aerosolized combination chemotherapy
In the present study, we have conceptualized and formulated a novel delivery vehicle which includes a combination of lipid nanovesicles and polymeric nanoparticles. Main aim of the study is to devise a nanoscale platform technology [...]
Synthesis of amphiphilic block copolymers to deliver HSP90 inhibitors for colorectal tumors
In this article, we present pH-sensitive and small size nanoparticles as carrier to encapsulate 17-AAG. We anticipate that this platform will provide a new strategy for cancer therapy.
The Development of Stealth Poly-Ɛ-Caprolactone Nanoparticles For the Delivery of Bioactive Agents
Polyesters have gained a lot of prominence because of their use in drug delivery. They are the most widely used polymers in biomedical applications because they are biocompatible, non-immunogenic, non-toxic and are approved for use [...]
Cellular uptake and cytotoxic effect of broccoli phytochemical based gold nanoparticles (B-AuNPs): Enhanced cancer therapeutic efficacy
The interaction phytochemicals from Broccoli with gold salt results in dual reduction and surface capping to produce well-defined stable and biocompatible gold nanoparticles. The core sizes of B-AuNPs are in the range of 10–20 nm [...]
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Published: May 12, 2013
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topics: Biomaterials, Cancer Nanotechnology
ISBN: 978-1-4822-0586-2