Nanotech 2012 Vol. 3
Nanotech 2012 Vol. 3
Nanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)

Materials for Drug & Gene Delivery Chapter 3

In vitro anticancer activity of poly(3-hydroxybutyrate) nanoparticles loaded with antitumor drug Paclitaxel

Authors: S.G. Yakovlev, A.P. Bonartsev, D.V. Bagrov, Yu.M. Efremov, A.P. Boskhomdzhiev, E.V. Filatova, P.V. Ivanov, T.K. Makhina, G.A. Bonartseva

Affilation: A.N.Bach’s Institute of Biochemistry Russian Academy of Sciences, Russian Federation

Pages: 190 - 193

Keywords: poly(3-hydroxybutyrate), nanoparticles, drug delivery

We have produced nanoparticles loaded with antitumor drug paclitaxel. Operated nanospheres were prepared on the base of a biodegradable and biocompatible polymer of bacterial origin, poly(3-hydroxybutyrate) (PHB). PHB nanoparticles with paclitaxel (230±55 nm in diameter) were obtained and investigated. It was shown that nanospheres loaded with paclitaxel caused inhibition of cell growth of breast cancer cell culture MFC-7 during 72 hours incubation in concentration dependent manner. Moreover, the in vitro antiproliferative action of biopolymer drug release system was more effective that antitumor action of commercially available paclitaxel drug dosage form, Taxol. Antiproliferative action of biopolymer nanoparticles was valid even after its incubation in buffer solution at 37°C for 45 days.

ISBN: 978-1-4665-6276-9
Pages: 818
Hardcopy: $209.95