Nanotech 2011 Vol. 1
Nanotech 2011 Vol. 1
Nanotechnology 2011: Advanced Materials, CNTs, Particles, Films and Composites

Nanoscale Materials Characterization Chapter 1

siRNA Delivery Using Biodegradable Nanoparticles for Breast Cancer Therapy

Authors: S. Abbasi, P. Arghya, K. Afshan, S. Prakash

Affilation: McGill University, Canada

Pages: 74 - 76

Keywords: nanoparticles, biodegradable, siRNA, breast cancer

Polyethylenimine (PEI)-coated human serum albumin (HSA) nanoparticles form suitable biocompatible carriers for therapeutic molecules. Small interfering RNA (siRNA) molecules have suggested great promise as a future therapy for breast cancer. In order to overcome the problems of degradation and low cellular transfection associated with siRNA, PEI-HSA nanoparticles are used. These nanoparticles are characterized to allow efficient delivery of siRNA to MCF-7 breast cancer cells.

ISBN: 978-1-4398-7142-3
Pages: 882
Hardcopy: $199.95