Drug Delivery

In Vivo Toxicity Study of Gold Composite Nanodevices for use in Imaging and Radiotherapy

Khan M.K., Nair B., Kasturirangan V., Kariapper M.S.T., Nigavekar S.S., Toth K., Rustum Y.M., El-Jawahri A., Bizimungu R., Lesniak W., Balogh L.P., Roswell Park, US

We previously reported on the in vitro toxicity assessment of differently charged dendrimer-gold nanocomposites on normal cells (human endothelial cells) and prostate cancer cells (Khan et al., 2008). In this study we evaluate the in [...]

Imprint Lithography-Based, Multimodal Contrast Agents and the Effect of Shape and Size on Biodistribution

Herlihy K.P., Merkel T.J., DeSimone J.M., UNC Chapel Hill, US

Polymer research and modern medicine are at a critical juncture. Many state of the art, small molecule therapeutics are difficult to deliver effectively because of poor solubility and rapid elimination by the reticuloendothelial system. In [...]

Synthesis and Biopharmaceutical Characterisation of a New Poly hydroxyethyl

Qi X-H, Lin W., He Q., Guan X-H, Nanjing Medical University, CN

A promising approach to improve drug delivery is to modify a polymeric backbone structure by means of copolymerization. Such obtained macromolecular prodrugs (polymer–drug conjugates) may offer many advantages compared to other drug delivery systems: increased [...]

Formulation and Development of Novel Insitu Nasal Gel Containing Glibenclamide Nanoparticles

Gohel M.C., Par R.K., Patel K.D., L.M. College Of Pharmacy, IN

To provide an alternative route (non-swallowing) and compliance to patient (controlled release), nasal delivery of sulfonylureas is one of the best option among other routes for type II diabetes. Glibenclamide was selected as a model [...]

Diskettes of mucoadhesive polymeric nanoparticles for oral (buccal) transmucosal delivery of Fluoxetine hydrochloride: formulation and characterization

Sapre A., Parikh R., Gohel M., L.M. College Of Pharmacy, IN

Nanoparticles based mucoadhesive system (diskettes), an alternative novel transmucosal (buccal) delivery of Fluoxetine hydrochloride (antidepressant drug, highly first pass effect) was developed. In this study, the drug was encapsulated into Sodium / Calcium salts of [...]

Modeling of Polymer-Drug Interactions in Biodegradable Tyrosine-Based Nanospheres Using Molecular Dynamics Simulations and Docking

Costache A.D., Sheihet L., Knight D.D., Kohn J., Rutgers University, US

The intensive labor and high cost of developing new vehicles for the delivery of drugs in a controlled manner, highlights the need for a change in their discovery process. Predictive computational models can be used [...]

Paclitaxel-functionalized aspragalan-calcium phosphate nanoparticles

He Q., Zhang X.Z., Yaun W.M., Zhau D.M., Fang Z.Q., Gang X.H., Nanjing Medical University, CN

Paclitaxel (PTX) is an important anticancer agent. Its aqueous solubility is very low; hence the available formulation of PTX for clinical use consists of Cremophor EL, which has been associated with several hypersensitivity reactions. In [...]

Process Development and Industrial Manufacturing of Nanotechnology-Based Pharmaceuticals

Hassan E., Gumudavelli S., Pharmaceutics International Inc. (Pii), US

Process design and development of oral, topical and parentral nanotechnology-based pharmaceuticals are presented. Factors affecting process output and scale-up choices for various dosage forms are discussed with emphasis on critical parameter control and optimization. For [...]

Effect of nanomeric structured micelles on metabolic kinetic study of two CNS drugs

Singh N., Nema N., Rawat L., Pandey A., H.S. Gour University, IN

Depression is estimated to affect nearly 340 million people worldwide and 18 million people in the US at any given time [1-2], making it the third most costly and disabling illness in the US [3-8]. [...]

Mechanism of Nitroimidazole Coated Magnetic Nanoparticles Embedded in Micro-organisms as Delivery Systems

Goel N., Sharma R., Post Graduate Institute of Medical Science, IN

Avirulent Bacteria and parasites act as “tiny missile like carriers” capable to carry the magnetic nanoparticles (NMP) together with anticancer or radiosensitizer drugs at the tumor site. We compared the iron-oxide particles binding characteristics with [...]

Newer Methods of Nanoparticle Synthesis: Nitroimidazole properties with Nanometal oxides in Polymer Cages

Khan R.A., Sharma R., Florida State University, IN

Nitroimidazoles are radiosensitizers and hypoxia detecting chemosensitizers. Intially nitroimidazoles were single dose antibiotic drugs. Recently, nitroimidazole derivatives have emerged as multifunctional “drug-biomarker monitors” chemical compounds with importance in treatment of tumors, monitoring hypoxia and safer [...]

Microparticles on the Basis of Segmented Polyurethanes for the Treatment of Tuberculosis

Batyrbekov E.O., Iskakov R., Zhubanov B., Institute of Chemical Sciences, KZ

The objective of the research is to develop a new drug delivery system based on polyurethane microparticles for the treatment of tuberculosis by pulmonary administration to the lungs. The synthesis and characterization of polyurethane microcapsules [...]

Fashioning of Polymer Multi-functional Nanovector Microparticle Delivery System by High Definition Microextrusion

Gabriele P.D., Hogan A., D’Ottavio J., Flemmens M., Weir M., ARmark Authentication Technologies, LLC, US

Considerable advances have recently been achieved in the development of nano-scale particles for cancer diagnostics and therapies. ARmark Authentication Technologies, LLC has developed a new technology platform to produce stable multifunctional polymeric microcarrier delivery vehicles [...]

Action of Paclitaxel pH-Sensitive Liposomes on B16F1 Melanoma Cells

Karanth H., Murthy R.S.R., The M.S. University of Baroda, IN

Long circulating pH-sensitive liposomes loaded with Paclitaxel were developed and characterized for the encapsulation efficiency, release characteristics and its action on B16F1 melanoma cells (low metastatic). Paclitaxel loaded pH-sensitive liposomes showed better release pattern and [...]

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