Nanotech 2008 Vol. 2
Nanotech 2008 Vol. 2
Nanotechnology 2008: Life Sciences, Medicine & Bio Materials - Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2

Drug & Gene Delivery Systems Chapter 4

Radiolabelled Microspheres As a Delivery System For Targetad Radiotherapy

Authors: G.P. Bandopadhyaya, J. Shukla

Affilation: All India Institute of Medical Sciences, India

Pages: 398 - 400

Keywords: microspheres, double emulsion solvent evaporation, cytotoxic, MTT

99mTc(V)DMSA (Dimercaptosuccinic acid) is a well-known radiopharmaceutical for imaging neurogenic tumors. 188Rhenium, a beta radiation emitter with 2.2 MeV energy having half life of 16.9 hours is a therapeutic analogue of imagable 99mTechnetium was introduced for targeted therapy.188Re(V)DMSA encapsulated PLGA microspheres were prepared, using 10% of PVA concentration, by double emulsion solvent evaporation technique. Microspheres of 0.2-2.0 micron were prepared. Re-188(V)DMSA-PLGA microspheres were incubated with cultured Glioma cells (U87MG) for the assessment of in-vitro cell survival.

ISBN: 978-1-4200-8504-4
Pages: 808
Hardcopy: $159.95