Papers:
Effect of Medical Device Substrate Material on Nanoparticulate Silver Efficacy
Silver is one of the oldest known natural antimicrobial materials, the active form being the Ag+ ion, which disrupts critical cell functions in bacteria. Reducing the size of silver particles to the nano-scale regime increases [...]
Nanomaterial: A realistic business case for Pharma
Main points from a pharma perspective: Review nanotech’s current position Nanotech and its realistic potential Nanotech and the barriers into the clinic GSK’s position on the subject matter
Towards nanosized particles in pharmaceutical industry
The pharmaceutical industry is facing the problem of an increasing number of drug substances in development which are either poorly water soluble or show pH dependency of solubility. Drug targeting and tailored delivery poses additional [...]
Multiplexed Proteolytic Enzyme Assay Based on Energy Transfer between Quantum Dots and Gold Nanoparticles
Oh Y.H., Kim H-S, Kim Y.P., Kim H-S, Kim Y.P., Korea Abvanced Institute of science and Technology, KR
Proteases are key enzymes that regulate both normal and malignant tumor progress. Evaluating these enzymes and their inhibitors, therefore, has a great potential to diagnostics or therapeutic treatment against specific diseases or disorders. We have [...]
2-Nitroimidazole as Potential Nanoprobe in Hypoxia Imaging by MRI/PET
2-Nitroimidazole is radiosensitizer and serves as imaging contrast agent by 19F- and 31P MR methods. Despite the success of mesonidazole and SR-4554 compounds, very little is known of its hepato-cytotoxicity if it can be potential [...]
Biomolecular activity switch: an application of metallic nanoparticle plasmon resonance
Alper J., Wijaya A., Crespo M., DeFlores L., Tokmakoff A., Hamad-Schifferli K., Massachusetts Institute of Technology, US
Specific external control of biomolecular activity is a critical step in harnessing the power of nature’s molecular machinery. We propose and demonstrate one control method, a biomolecular activity switch. Since proteins are the primary macromolecule [...]
Multifunctional nanoparticle platforms for pathogen diagnostic applications
Infectious diseases and bioterrorism are of tremendous global concern, and our group is interested in developing superparamagnetic nanoparticle platforms that can aid in the magnetic extraction/concentration and detection of harmful pathogens. This has led to [...]
Investigating Helical Rosette Nanotubes and Nanocrystalline Hydroxyapatite as Novel Bone-like Biomaterials for Orthopedic Applications
The objective of this study was to create a novel biomimetic hydrogel composite based on helical rosette nanotubes (HRNs) and nanocrystalline hydroxyapatite (HA). HRNs are newly-developed self-assembled nanomaterials with DNA base pair building blocks. HRNs [...]
Exploring the behavior of concentrated collagen, approaches to tailor biomimetic materials
Gobeaux F., Mosser G., Anglo A., Panine P., Davidson P., Giraud-Guille M.-M., Belamie E., Ecole Pratique des Hautes Etudes, FR
Dense ordered collagen matrices can be obtained by fine tuning the electrostatic interactions in highly concentrated solutions of type I collagen. Such biomimetic fibrillar materials have a high application potential in the field of tissue [...]
Enhancement of in vitro Capillary Tube Formation by Substrate Nanotopography
Bettinger C.J., Zhang Z., Gerecht S., Borenstein J.T., Langer R., Massachusetts Institute of Technology, US
Controlling the morphology and function of cells using substrate nanotopography is a phenomenon that can be utilized in a variety of fields including tissue engineering and regenerative medicine. In this work, we explored the possibility [...]
Effect of functionalization on the self-assembling propensity of beta sheet forming peptides
Taraballi F., Campione M., Vescovi A.L., Sassella A., Hwang W., Paleari A., Gelain F., University of Milan-Bicocca, IT
Synthetic polymers and bioinspired fibrous materials have a significant impact in medicine in the recent years. The design and fabrication of new bio-materials has a great influence in several scientific and medical communities. The potential [...]
Synthesis of Dextran-Coated Nanoceria with pH-dependent Antioxidant Properties
Cerium oxide nanoparticles (nanoceria) are potent free radical scavengers with neuroprotective, radioprotective, and anti-inflammatory properties. However, most synthetic procedures for nanoceria results in nanoparticles with poor water solubility or synthesized by procedures involving toxic solvents, [...]
Mechanisms of Cellular Interaction, Binding and Internalization of Functionalized Carbon Nanotubes
The development of nanomaterials for biomedical and biotechnological applications is an area of research that holds great promise and intense interest. Carbon nanotubes (CNT) are thought to lead to novel types of nanomedicines. In our [...]
Effect of Ligand Nature on the Kinetics and the Redistribution of Quantum Dots in Mice
The meeting of nano-materials with biology has produced a new generation of technologies that can profoundly impact biomedical research. The NIR emitting window (650-900 nm) is appealing for in vivo optical imaging because of the [...]
Optimizing nanoparticle functionalization for quantum dot formation
Utilizing state-of-the-art molecular dynamics simulation techniques, we have developed a methodology for determining the gross functionalization parameters required to promote formation of small, compact, and stable nanoparticle clusters in aqueous solutions. The ultimate goal of [...]
Chip-Based Energy Transfer System between Quantum dots and Gold Nanoparticles for Analysis of Protein Glycosylation
Protein glycosylation is one of the most essential processes in the living systems, and often is a major target for developing therapeutics and diagnosis. We have developed a chip-based energy transfer system between quantum dot [...]
Functionalized Mesoporous Silica Nano-particle for Optical Bio-detection
Maki G., Maki W.C., Mishra N.N., Filanoski B., Rastogi S.K., Cameron E., Maki G., Maki W.C., University of Idaho, US
Mesoporous silica nano-particles were immobilized with luciferase and antibodies for immune-bioluminescence detection of Staphylocuccus aureus enterotoxin B (SEB) and C (SEC). Mesoporous silica nano-particles were used as matrix to immobilize antibodies specific for enterotoxins and [...]
Local temperature measurement near remotely heated,ultra-small gold nanoparticles
Gupta A., Denver H., Borca-Tasciuc D-A., Joshi A., Kane R., Hella M., Rensselaer Polytechnic Institute, US
This work presents a novel technique to measure the temperature in the vicinity (~3.5 nm) of a remotely heated, ultra-small gold nanoparticle. The temperature measurement is carried out employing fluorescent thermometry and core/shell CdSe quantum [...]
Gold Nanoparticle Bioconjugates for Biomolecular Imaging and Detection
Gold nanoparticles and colloids have been used for a long time in biomolecular imaging and detection. With further understanding on many of the electrical and optical properties of gold nanoparticles revealed recently, the application of [...]
Dye Coded Nanoparticle as SERRS Labels for Ultrasensitive Detection of Proteins and Antibodies
We have developed a novel surface enhanced resonance Raman scattering (SERRS) detection method that is amenable for almost any biological target. By utilising the information rich spectrum obtained from SERRS we show that we can [...]
Functionalized Inorganic Nanostructures for Biomedical Applications
Bonroy K., Jans H., Jans K., Van de Broek B., Van Meerbergen B., Van Summeren A., Jans H., Jans K., Reekmans G., Van de Broek B., Van Meerbergen B., Van Summeren A., Van de Broek B., Van Meerbergen B., Van Summeren A., Huang C., Stakenborg T., Trekker J., Willems M., Bartic C., Verhaegen K., Borghs G., IMEC, BE
Nanomaterials differ significantly from other materials due to two factors: increased surface area and quantumsize effects. These factors can enhance properties such as reactivity, strength and physical characteristics. Due to these characteristics, the coupling of [...]
Enrichment of serum phosphopeptide by nanoparticles to identify cancer biomarker
The role of kinases in transformation and cancer progression is established. We hypothesize that The role the specific phosphoproteins/phosphopeptides will be present in cancer patient serum as leak proteins and their isolation and identification will [...]
The Study of the Nanocontact Imprint with Aminosilane
Shen F.Y., Chen J.H., Chen N.H., Lam K.Y., Chen J.H., Chen N.H., Huang F.S., National Tsing Hua University, TW
The purpose of this paper is to develop nano-contact imprint technology with simple process by using soft HSQ (hydrogen silsesquioxane) mold transfer aminosilane ink on HSQ and glass substrates with binding Glutraic dialdehyde (GA) and [...]
Proton Uptake by Dormant Bacterial Spores
A dormant bacterial spore is regarded as a natural ionic reservoir, i.e. a system capable of changing the external pH or ionic strength by accumulating or releasing ions. In this work, we introduce a method [...]
Modified AFM Probes for Nanoscale Biomolecular Recognition Studies
Biomolecular interactions, which are responsible for many physiologically important processes, can be studied by molecular recognition force microscopy (MRFM). In MRFM, nanoNewton scale single molecule interactions are observed and quantified one by one as an [...]
Investigating electrospun nanofibrous scaffold mechanical properties
There has been a considerable growth and development in electrospun nanofibers for research activity, as well as commercial fabrication over the past couple of decades. These continuous nanofibers are solution driven exclusively by an electric [...]
Synthesis and characterization of Hyaluronan – Gold Nanoparticles: A nanostructured material for biomedical applications
Hyaluronan (HA) is a glycosaminoglycan with a number of biological roles, such as being a key structural component of extracellular matrix and an important mediator in the leukocyte adhesion and migration. HA is ubiquitous in [...]
Subcellular fractionation in a fluidic microsystem
Paulus A., Posch A., Hausmann M., Blankenstein G., Duong T., Kentsch J., Angres B., Stoll D., Stelzle M., NMI Natural and Medical Sciences Institute, DE
The availability of an easy-to-use, reproducible method for subcellular fractionation would significantly promote qualitative and quantitative analysis of subcellular protein composition. A microfluidic system with integrated electrodes was designed and fabricated allowing for dielectrophoretic manipulation [...]
Studies of Hybrid Nano-Bio-System: Single-Walled Carbon Nanotubes and Hydrogenase
Svedruzic D., Blackburn J.L., McDonald T.J., Heben M.J., King P.W., National Renewable Energy Laboratory, US
We have examined changes in single-walled carbon nanotubes (SWNT) optical signals upon addition of recombinant [FeFe] hydrogenases from Clostridium acetobutylicum or Chlamydomonas reinhardtii. We found evidence that novel and stable charge-transfer complexes are formed only [...]
Engineering of efficient biocatalysts using nanostructured mesoporous silicate carriers
Szymanska K., Bryjak J., Jarzebski A.B., Institute of Chemical Engineering, Polish Academy of Science, PL
Immobilization of free enzymes/proteins on water-insoluble mesoporous silica (MS) supports is often applied to obtain efficient biocatalysts for various applications. Three methods were applied for enzyme bonding onto MS: (1) physical adsorption with subsequent crosslinking [...]
Fabrication of Luminescent Superparamagnetic CdSe-QDs/SiO2/Fe3O4 nanocomposite particles
A new kind of water-soluble luminescent superparamagnetic nanocomposite particles has been synthesized using a modified Stöber method combined with an electrostatic assembly process. Fe3O4 nanoparticles with the size of 10 nm were uniformly coated with [...]
Electrospun Nanofibrous Membrane Biosensor for lactate
Electrospinning is a simple, non mechanical method used to produce non-woven fabrics of ultrafine fibers in the nanometer diameter range (nanofibers).This method is appropriated to obtain high-surface-area polymeric fibrous membranes and is a one-step process [...]
In-vitro and In-vivo Screenings of Electrospun Polycaprolactone-Carrageenan Nanofibrous Scaffolds for Tissue Engineering
Nanofiber scaffolds are potential materials in three-dimensional cell-culture media. Among the most common and attractive polymer used for this application is polycaprolactone (PCL). PCL is non-toxic, biodegradable and biocompatible synthetic aliphatic polyester. It is completely [...]
Sprayed Nanogels onto 2D and 3D Scaffolds as Novel Drug Eluting Coatings
Big advances are being achieved in the design of new implantable devices. The implant-induced inflammatory reaction remains a significant challenge in this field. Coated scaffolds capable of releasing bioactive agents for inhibiting totally or partially [...]
In Vitro and In Vivo Evaluations of Bioactive Poly(epsilon-caprolactone)–Organosiloxane Nano-Hybrid Developed as a Novel Bone Substitute
In this study, we evaluated the cellular behaviors of human bone marrow stromal cells (hBMSCs) on the surface of apatite pre-coated poly( -caprolactone)–organosiloxane nano-hybrid material (SiOPCL) and assessed the osteoconductivity of SiOPCL in the diaphyses [...]
Role of Nano-chirality and broken symmetry in hostile organism penetration of host cell DNA
We show that broken symmetry, at the nano level, of biomolecules is key to phage invasion of a host cell, and take-over of the cell’s RNA-DNA replication processes. We determined that perturbation of cellular water [...]
Biological influence of nanofibrous hydroxyapatite-polycaprolactone membrane on human periodontal ligament cell
Kim H.W., Kim T.I., Lee S.J., Ku Y., Rhyu I.C., Chung C.P., Han S.B., Kim H.W., Kim T.I., Seoul National University, KR
This study was performed to evaluate the effect of hydroxyapatite-coated nanofibrous polycaprolactone membrane on proliferation and differentiation of periodontal ligament cell which is necessary for periodontal regeneration. Hydroxyapatite-coated nanofibrous polycaprolactone membrane was fabricated through electrospinning [...]
Functional Polymersomes (Synthosomes) for Bioconversion and Selective Product Recovery
Güven A., Ihle S., Fioroni M., Schwaneberg U., Jacobs University Bremen, School of Engineering and Science, DE
The combination of natural proteins with polymer membranes allows the formation of a novel nanocompartment combining the mechanical, chemical, and biological stability of the amphiphilic block copolymer with the functional specificity of membrane proteins. Functional [...]
Journal: TechConnect Briefs
Volume: 2, Nanotechnology 2008: Life Sciences, Medicine & Bio Materials – Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: June 1, 2008
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topics: Biomaterials, Materials Characterization & Imaging
ISBN: 978-1-4200-8504-4