Authors: A. Bumb, PJ. Dobson, L. Fugger, P. Choyke, MW. Brechbiel
Affilation: National Cancer Institute/University of Oxford, United States
Pages: 1 - 4
Keywords: cancer diagnostics, imaging, nanoparticle, tri-imaging
We have created a potential targeted drug delivery platform with three imaging reporters by coupling the magnetic properties of USPIOs with near infrared fluorescence of Cy5.5 and gamma emissions of Indium-111 that is chelated to a targeting antibody. The nanoparticles have been characterized for surface charge by zeta potential measurements, structure by transmission electron microscopy and dynamic light scattering, optical response by fluorescence spectrophotometry, and magnetic properties with a superconducting quantum interference device. Cetuximab is being used to direct the particles to HER1-expressing tumors and a number of in vitro and in vivo studies have been conducted. Though there are many diagnostic applications of the current structure, the nanoparticle can also be developed into a drug delivery construct, where its superparamagnetic properties are utilized for hyperthermia and controlled drug release.