Nanotech 2007 Vol. 2
Nanotech 2007 Vol. 2
Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2

Cancer Diagnostics, Imaging & Treatment Chapter 9

Development of Nanoconjugate with Different Monoclonal Antibodies to Inhibit Molecular Targets Important for Tumor Angiogenesis

Authors: M. Fujita, N.M. Khazenzon, B.S. Lee, E. Holler, K.L. Black and J.Y. Ljubimova

Affilation: Cedars-Sinai Medical Center, United States

Pages: 760 - 762

Keywords: nanoconjugate, angiogenesis, tumor markers, tumor-specific drug delivery

Tumor cell-specific drug targeting is the major goal of nanotechnology-based platforms. A nanoconjugate Polycefin was synthesized for targeted delivery of antisense oligonucleotides and antibodies into tumors. The delivery of antisense oligonucleotides to α4 and β1 chains of a vascular basement membrane protein, laminin-8, suppressed its synthesis in vivo. Treatment of glioma-bearing rats significantly diminished tumor vascularity (p

ISBN: 1-4200-6183-6
Pages: 838
Hardcopy: $139.95