Authors: B.W. Maynor, G.M. Denison, J.P. Rolland, J.M. DeSimone
Affilation: Liquidia Technologies, United States
Pages: 255 - 257
Keywords: nanoparticles, imprint lithography, drug delivery, molecular imaging, microelectronics, nanofabrication, nanobiotechnology
We have developed scalable, “top-down” nanofabrication methodologies for the fabrication of polymeric and organic nanostructures for nanobiotechnology and materials engineering. These techniques use novel perfluoropolyether (PFPE) elastomers that possess superior nanoimprinting properties, including error-free nanoscale shape replication of microfabricated, self-assembled, and biological materials. We have used these materials to produce monodisperse, shape-specific organic nanoparticles of many compositions in a process that we call Particle Replication In Non-wetting Templates (PRINT) and for the fabrication of nanostructured surfaces for microelectronics. For pharmacological applications, we are able to fabricate valuable particulate agents such as monodisperse solid drug nanoparticles, targeted therapeutic delivery vectors, and molecular imaging agents. For microelectronics, we have demonstrated the ability to pattern relevant structures such as dual-damascene patterns with nanometer-scale resolution in a single step. We have combined the robust processing capabilities of the microelectronics industry with the flexibility and sophistication of traditional organic materials chemistry to produce unique nanostructured materials that should find many applications in nanomedicine and materials science.
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