Nanotech 2006 Vol. 2
Nanotech 2006 Vol. 2
Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Volume 2

Bio Sensors and Diagnostics Chapter 3

Detection of Small Molecule-Protein Binding with Amorphous Silicon Nanostructures

Authors: J. Lund, R. Mehta and B. Parviz

Affilation: University of Washington, United States

Pages: 186 - 189

Keywords: biotin, streptavidin, detection, nanowire, silicon, semicircle

We present the fabrication and characterization of a nano-scale sensor made of amorphous silicon (a-Si) for electronic detection of small molecule –protein binding. The main component of the detector is a nano-scale a-Si semicircle with a surface functionalized with receptor molecules. Upon exposure, target molecules bind to these receptors and effectively change the surface dipole moment of the semicircle. This change of dipole moment in turn bends the semiconductor bands at the surface resulting in a change in charge carrier density. Due to the extremely small cross section of the conductive path (50 nm x 50 nm), changes close to the surface significantly affect the apparent conduction in the semicircle and can be monitored electronically to determine the occurrence of molecular binding events.

ISBN: 0-9767985-7-3
Pages: 893
Hardcopy: $119.95