Nanotech 2006 Vol. 1
Nanotech 2006 Vol. 1
Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Volume 1

Nanoparticle Processes & Applications Chapter 4

Application of nanoparticle in photodynamic diagnosis for colorectal cancer

Authors: S.J. Yang, C.L. Peng, P.S. Lai, F.H. Lin and M.J. Shieh

Affilation: National Taiwan University, Taiwan

Pages: 471 - 474

Keywords: chitosan, 5-aminolevulinic acid, photochemical diagnosis, colon cancer

Photodynamic medicine is a novel approach for cancer therapy and diagonosis via different photosensitizers and suitable light source. The 5-Aminolevulinic acid (5-ALA) can be converted into protoporphyrin IX (Pp IX ) that can be utilized as a fluorescent probe for tumor detection, however, this biosynthetic pathway also can be occurred in normal flora, including E. coli, in the colon and rectum that influence the efficacy of tumor detection. In this study, 5-ALA was encapsulated in chitosan nanoparticles to prevent uptake of E. coli. This result implied that chitosan can exclude the influence of normal flora inside the gut and serves as an ideal vector of colon-specific drug delivery system. According to this concept, we designed a novel photodynamic detection system to enhance the accuracy of endoscopic diagnosis for early colorectal cancer.

ISBN: 0-9767985-6-5
Pages: 871
Hardcopy: $119.95