Authors: A. Prina-Mello, Z. Diao and J.M.D. Coey
Affilation: CRANN Research Laboratory, Ireland
Pages: 62 - 63
Keywords: magnetism, nanowires, cell separation, cell alignment,
In this paper we investigate the possibility of using magnetic nanowires in cell separation and manipulation. Ni, Co/Cr and Co/Fe nanowires made by electrochemical deposition in anodic aluminum oxide (AAO) templates. The combination between nanowires and different cells such as MC3T3 mouse fibroblasts, UMR-106 has been shown. There, cell viability with all the three kinds (Ni, Co/Cr and Co/Fe) of nanowires after combination was monitored. Magnetic cell separations were carried out following standardized conditions have achieved 75% purity and 75% yield. <br>Moreover, we were also successful in aligning the nanowires with cells in a 0.1 T uniform magnetic field. There, the axial of the magnetic nanowires internalised into cells can be aligned to the field direction with uniform magnetic field.<br>Therefore, a cell-nanowire interaction and living study will be addressed in the future in order to understand the intrinsic mechanisms responsible for cell internalization and alignment.
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