Authors: M.S. Bae, I.C. Kwon, S.Y. Jeong and K.Y. Lee
Affilation: Hanyang University, Korea
Pages: 164 - 167
Keywords: chitosan, self-aggregate, gene, adriamycin
A number of novel delivery systems have been developed including the entrapment of drugs, proteins, antigens, or genes in small vesicles or within polymeric matrices. Colloidal delivery systems such as liposomes, microemulsions, and polymeric micelles have been widely investigated to date, as these formulations may reduce unwanted side effects and may improve the therapeutic effects. We demonstrated that stable chitosan self-aggregates with the diameter of about 150 nm can be prepared, and their characteristics were dependent on the molecular weight of chitosan, degree of substitution of deoxycholic acid, and pH and ionic strength of the medium. These self-aggregates may find useful applications in the area of drug delivery for therapeutic purposes.