Nanotech 2001 Vol. 1
Nanotech 2001 Vol. 1
Technical Proceedings of the 2001 International Conference on Modeling and Simulation of Microsystems

Micro and Bio Fluidics Chapter 6

Three-Dimensional Single Step Flow Sheathing in Micro Cell Sorters

Authors: G. Goranovic, I. Perch-Nielsen, U.D. Larsen, A. Wolff, J. Kutter and P. Telleman

Affilation: Bio/Chemical MicroSystems, Denmark

Pages: 242 - 245

Keywords: cell sorting, microfluidics, coaxial sheathing, simulations

We present a novel microstructure that enables 3 dimensional hydrodynamic focusing of cells in a pressure driven micro cell sorter. This so-called "chimney" structure for single step coaxial sheathing was designed and optimized through simulation, and then successfully micromachined in silicon as part of an integrated micro cell sorter. Coaxial sheathing was clearly demonstrated by velocity distribution experiments and shown to be in accordance with simulation data. The "chimney" structure is easy to machine and can be monolithically integrated with a variety of other microfluidic structures.

ISBN: 0-9708275-0-4
Pages: 638