Nanotech 2001 Vol. 1
Nanotech 2001 Vol. 1
Technical Proceedings of the 2001 International Conference on Modeling and Simulation of Microsystems

Micro and Bio Fluidics Chapter 6

Analysis of Sample Transport in Capillary Electrophoresis Microchip Using Full-Scale Numerical Analysis

Authors: S. Krishnamoorthy, J.J. Feng and V.B. Makhijani

Affilation: CFD Research Corporation, United States

Pages: 206 - 209

Keywords: electrophoresis, ionization, microfluidics, CFD-ACE+, stacking

An implicit finite-volume numerical scheme has been developed to solve the three-dimensional transport equations along with fully-coupled ionization equilibria in acid/base systems. The scheme solves conservation equations for mass and momentum while satisfying the electroneutrality condition in a sequential fashion until convergence is achieved. The electric field is computed based on current conservation formulation. We employ this computational analysis/design tool to study the time evolution of a sample containing several analytes in a capillary electrophoresis microchip. The phenomena of sample stacking and tailing due to conductivity differences and the effect of degree of ionization are analyzed and compared with experimental data of Ermakov and Righetti [1].

ISBN: 0-9708275-0-4
Pages: 638

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