Nanotech 2001 Vol. 2
Nanotech 2001 Vol. 2
Technical Proceedings of the 2001 International Conference on Computational Nanoscience and Nanotechnology

Computational Biology and Molecular Design Chapter 1

Stochastic Simulations of Cell-Cell Signalling in Hepatocytes

Authors: M.E. Gracheva, R. Toral and J.D. Gunton

Affilation: Lehigh University, United States

Pages: 9 - 12

Keywords: stochastic, intercellular, calcium waves, gap junctions, hepatocytes.

We present results of a Monte Carlo simulation of stochastic effects for two models of intercellular calcium wave propagation in rat hepatocytes. Both models involve gap junction diffusion by a second messenger. In general taking into account the stochastic effects improves agreement with experiment. Both stochastic models exhibit baseline °uctuations and variations in the peak heights of Ca 2+. In addition, we find for one model that there is a distribution of latency times, rather than a single latency time, with a width which is comparable to the experimental observation of spike widths. We also ¯nd for the other model with low gap junction diffusion that it is possible for cell multiplets to oscillate independently initially, but to subsequently become synchronized.

ISBN: 0-9708275-3-9
Pages: 218