NSTI Nanotech 2009

Characterizing Nanoparticles for Toxicology: The Role of Residual Organics

A.M. Boyd, J.D. Fortner, E. Quevedo, J. Costanza, S. Moran, K.D. Pennell, V.L. Colvin
Rice University, US

Keywords: C60, THF, Residual Organics


Toxicological studies of nanomaterials, particularly carbon based systems, have been plagued by poor reproducibility and contradictory conclusions often ascribed to varying methods of production and purification. Water stable C60 aggregates are no exception and have undergone extensive scrutiny the past several years due to, in part, the uncertainty introduced by using organic transfer solvents such as toluene or tetrahydrofuran (THF). Here we analytically quantify and delineate residual transfer solvent concentrations and corresponding degradation products using headspace gas chromatography coupled with mass spectroscopy (GC-MS) and solution-state, nuclear magnetic resonance spectroscopy (NMR).
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