2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

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Clean Technology 2008

Numerical Analysis of Nanofluidic Sample Preconcentration in Hydrodynamic Flow

Y. Wang, K. Pant, W. Diffey, Z. Chen, S. Sundaram
CFD Research Corporation, US

streaming potential, nanofluidic, electric double layer, preconcentration

This paper presents the first, high-fidelity numerical study of nanofluidic streaming potential-based sample preconcentration. Parametric analysis is performed to capture the critical effects of pressure and background electrolyte (BGE) concentration on preconcentrator performance. Our studies demonstrate that ion-polarization and electric field barrier can be established at micro-nano-channel interfaces and substantial sample enrichment (>10,000-fold) can be readily achieved using hydrodynamic flow. The results can be used for practical design and operational protocol development for novel sample preconcentrators.

Nanotech 2008 Conference Program Abstract