2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

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Whispering Gallery Mode lab on a chip for optical bio sensing: comparison with Surface Plasmon Resonance

A. Fran├žois, S. Krishnamoorthy, M. Himmelhaus
Fujirebio Inc., JP

biosensor, whispering gallery mode, microsphere

In this paper, we investigate the use of whispering gallery modes (WGM) of spherical micro resonators of 10mm diameter or smaller, as a promising means of optical biosensing on microscopic scale. So far, potential application of WGM for biosensing have been demonstrated by measuring both non-specific and specific interactions between high affinity molecules such as biotin and streptavidin. However, the behavior of the system with respect to the WGM mode positions remains unknown when low affinity antibody-antigen interactions, which are most common in biology, are measured. Moreover, no direct comparisons of the capability of WGM for biosensing with existing mature techniques have been performed so far. Therefore, we present a direct comparison between WGM and another evanescent field technique, Surface Plasmon Resonance, for both high and low affinity specific interactions. A discussion of the advantages and disadvantages of the chosen WGM sensors over the well-established SPR technique is presented.

Nanotech 2008 Conference Program Abstract