2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

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Clean Technology 2008

Production of Polymer Nanosuspensions Using MicrofluidizerTM Processor Based Processes

T. Panagiotou, S.V. Mesite, J.M. Bernard, K.J. Chomistek and R.J. Fisher
Microfluidics, US

polymers, nanosuspensions, PLGS, drug delivery, microfluidizer

Two techniques are reported here that can create nano-suspensions of many different polymers types with varying particle sizes by controlling the formulation and process variables. Microfluidics Reaction Technology (MRT) was used with the solvent anti/solvent precipitation technique. Particle size distribution can be controlled by varying parameters such as processing pressure, degree of supersaturation and the ratio of solvent and anti-solvent streams. The solvent emulsion evaporation technique was implemented using a Microfluidizer Processor; i.e., dissolving a polymer in a solvent, creating a nanoemulsion with an immiscible continuous phase, then solvent evaporation to produce the nanosuspension. Particle size distributions can be controlled by varying process parameters and/or formulation. Nanosuspensions in the range of 50-500 nm with many different polymers have been created successfully using both techniques. Poly(epsilon-caprolactone) (PCL) and poly(D,L-lactide-co-glycolide) (PLGA) are two polymers that have been extensively used for parenteral drug delivery. A PCL suspension with a mean particle size of 220nm was created using MRT by mixing a 20 mg/ml (PCL/acetone) solvent stream with water at a ratio 1:10 (solvent:anti-solvent). PCL nanosuspensions have also been created by dissolving the PCL in methylene chloride, forming an emulsion in water and then vaporizing the solvent.

Nanotech 2008 Conference Program Abstract