2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

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TechConnect Summit
Clean Technology 2008

Lipid core near infrared imaging agent for in vivo whole body imaging

A. Papagiannaros, A. Kale, D. Chovatia, T. Levchenko, W. Hartner, D. Mongayt, V. Torchilin
Northeastern University, US

quantun dots, micelles, near infrared, imaging, tumors

Introduction: Whole body near infrared in vivo imaging offers results with high sensitivity and precision. This method’s advantage include easy handling, improved versatility and cost effectiveness and noninvasive and images captured in real time. Aims of the Study: 1. To visualize the biodistribution of nanoparticles, a task conventionally done using radioactivity 2. To develop nanosized contrast agents. Materials and Methods: Micelles encapsulating Alexa750 or near infrared quantum dots were produced. Tumor and non tumor-bearing animals were visualized in a Kodak In Vivo Image Station FX and images were analyzed using the Kodak software or NIH Image J. Results and Discussion: Alexa750 micelles fluorescence is higher than the commercially available lipospheres, reaching maximum within two hours; quantum dot incorporating micelles distribution is similar while commercially available pegylated quantum dots fluorescence is limited to the tumor area and maximum fluorescence is reached only after several hours. Quantification of the fluorescence was done using the Kodak Image Analysis Software or NIH Image J. Conclusions: An optical molecular imaging system in the near infrared region was developed that allows both the visualization of the biodistribution of nanoparticles and tumor imaging in vivo. Early results are promising for its future development.

Nanotech 2008 Conference Program Abstract