2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

Partnering Events:

TechConnect Summit
Clean Technology 2008

Multifunctional Polymeric Nanosystems for EGFR Gene Silencing

S. Pai, M. Amiji
Northeastern University, US

muiltifunctional polymeric nanoparticles, siRNA

Multifunctional polymeric nanoparticles with an average size of 200nm could be prepared using the solvent displacement technique. Cetyltriethylammonium bromide (CTAB) surface-modified poly(ethylene oxide)-modified poly(epsilon-caprolactone) (PEO-PCL) nanoparticles encapsulated PTX and siRNA with a loading efficiency > 95%. The multifunctional polymeric nanoparticles could successfully deliver siRNA and chemotherapeutic drug simultaneously to cancer cells to silence EGFR and enhance cell kill respectively

Nanotech 2008 Conference Program Abstract