2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

Partnering Events:

TechConnect Summit
Clean Technology 2008

Synthesis and Surface Modification of Gold Nanoparticles for Biomolecular Imaging and Detection Applications

Q. Dai, J. Coutts, X. Liu, L. Austin, Q. Huo
University of Central Florida, US

gold nanoparticles, surface modification, bioimaging, biodetection

Gold nanoparticles have many unique properties such as large optical absorption and light scattering cross section, surface plasmon resonance, surface-enhanced Raman scattering that make them very promising optical probe materials for biomolecular imaging and detection. However, there are many remaining problems and challenges that prevent the extensive applications of gold nanoparticles in bioconjugation chemistry. The surface chemistry of the nanoparticles plays a critical role in retaining the biological function of the biomolecules conjugated to nanoparticles. Currently available synthetic methodologies, however, are not satisfactory at providing gold nanoparticles with appropriate surface chemistry for biological applications. Through our study, we have explored a number of methods to increase the water-solubility, biocompatibility and biostability of gold nanoparticles. We conducted bioconjugation study of the surface-modified gold nanoparticles with different antibodies and DNA probes. The applications of these bioconjugated gold nanoparticles for cancer biomarker detection and cell imaging will be presented in the talk.

Nanotech 2008 Conference Program Abstract