2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

Partnering Events:

TechConnect Summit
Clean Technology 2008

Cellular-scale hydrodynamics

H. Stone
Harvard University, US

micro fluidic, cellular, hydrodynamics, ATP

We describe several microfluidic approaches for cellular-scale hydrodynamics. In particular, (i) we consider the influence of shear stress on the kinetics of ATP release from red blood cells that flow through constrictions, (ii) we demonstrate a microfluidic technique for measuring Michaelis-Menten rate constants, which should be broadly applicable to enzymatic reactions, and investigate the idea using experiments, numerics, and scaling arguments, and (iii) we present an electrohydrodynamic technique for separating by size giant unilamellar vesicles in polydisperse suspensions. These projects have in common the use of hydrodynamic principles to explore quantitatively new questions in mechanotransduction, nonlinear chemical kinetics, and separations.

Nanotech 2008 Conference Program Abstract