2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

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TechConnect Summit
Clean Technology 2008

Ceramic Nanophosphors for Upconversion Bioimaging

K. Soga, Y. Saito, M. Kamimura, Y. Nagasaki
Tokyo University of Science, JP

bioimaging, rare earth, upconversion, near infrared

Fluorescence bioimaging (FBI) is one of the most important technologies for biomedical applications. Current problems of the FBI are photo damages onto the probes themselves and substances in biological system and strong scattering due to the use of the short-wavelength excitation light (UV or VIS). Rare-earth doped ceramic nanophosphors (RED-CNP) are known as nano-sized phosphors show infrared-to-visible upconversion. By using this phenomenon, the photo damages can be avoided by the use of near infrared (NIR) excitation light. The RED-CNP are easy to be agglomerated and non-specifically interact with substances under physiological conditions. In this study, we prepared the yttrium oxide nanoparticles doped with Er ions, which were modified with PEG based polymer for avoiding the agglomeration and non-specific interaction in physiological conditions. By introducing biotin end to the PEG-based polymer, specific interaction of the UC probe with avidin was also issued. The dispersion stability and specific interaction are issued by sedimentation test and upconversion fluorescence plate assay, respectively.

Nanotech 2008 Conference Program Abstract