2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

Partnering Events:

TechConnect Summit
Clean Technology 2008

Biosensor Instrumentation with attoFarad Resolution for Electrochemical Impedance Measurements at the Nanoscale

G. Ferrari, M. Carminati, F. Gozzini, M. Sampietro
Politecnico di Milano, IT

attinity biosensors, biomolecular detection, low noise, electrochemical impedance spectroscopy

A complete potentiostatic measurements systems and a single-chip front-end for detection of sub-pA currents are presented here. This instrumentation is aimed at the realization of affinity biosensors by means of impedimetric detection of conformational changes of the bio-macromolecules complexes binding to target analytes. Both implementations are based on an innovative integrator / differentiator topology which enables the achievements of ultra low noise sensitivity (7 e 3 fA/sqrt(Hz) respectively) over a continuous wide bandwidth (DC – 1MHz). The potentiostat system allows performing cyclic voltammetry, electrochemical impedance spectroscopy and impedance tracking in time domain on interfacial systems whose dimensions can range from millimetric down to sub-micrometric scale, with a resolution of tens of aF’s. Along with instrumentation design, the results of its thorough experimental characterization are illustrated.

Nanotech 2008 Conference Program Abstract