2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

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TechConnect Summit
Clean Technology 2008

Controllable g5p Protein Mediated Assembly and Disassembly of DNA Conjugated Nanoparticles

S-K Lee, M.M. Maye, Y-B Zhang, O. Gang, D. van der Lelie
Brookhaven National Laboratory, US

g5p, DNA conjugated nanoparticles, assembly

Controllable assembly of non-complementary single stranded DNA (ssDNA) conjugated nanoparticles was achieved using the gene 5 protein (g5p) as the molecular glue via binding to two anti-parallel ssDNAs. Hybridization with complementary ssDNA, which triggers the g5p-ssDNA complex to dissociate, permits to control both assembly and disassembly of nanoparticles at room temperature without thermal treatment. This concept has great potential for the design of sensors for DNA and RNA detection, and will also help to improve the way for designing of protein incorporated functional nanostructures.

Nanotech 2008 Conference Program Abstract