2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Droplet-based Segregation and Extraction of Concentrated Samples

C.R. Buie, P. Buckley, J. Hamilton, K.D. Ness and K.A. Rose
Lawrence Livermore National Laboratory, US

microfluidics, two phase flow, droplet

Incorporating microfluidic-based technologies into bio-analytical instruments has many benefits including reduced sample consumption, faster response times, and improved sensitivity. To achieve these benefits, microfluidic analysis often requires sample concentration and separation techniques, e.g., isotachophoresis or electrophoretic separation, to isolate and detect analytes of interest. In addition to these techniques, complex or scarce samples may also require an orthogonal separation and detection method or off-chip analysis for confirmation of results. To perform these additional steps, the concentrated sample plug must be extracted from the primary microfluidic channel with minimal sample loss and minimal dilution. This study explores sample extraction utilizing simple droplet and bubble generation techniques with precise metering and control of nanoliter fluid volumes. We investigated two techniques; injection of immiscible fluid droplets into the sample stream and injection of the sample into an immiscible fluid stream.

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Nanotech 2007 Conference Program Abstract


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