2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Using Electron Tunneling for Direct Sequencing of DNA

J. Lund, J. Dong, R. Mehta, M. Rahimi, D. Ryan and B.A. Parviz
University of Washington, US

DNA, sequencing, IETS, tunneling, STM

Genomic information has assumed a central role in the way biology in general and cell function in particular are understood today. Methods that can sequence DNA rapidly, accurately, and cost-effectively are needed in order to expand our knowledge of the core biology and realize the promise of genomics in areas such as personalized medicine. Here, we report an electronic method that can directly read bases using inelastic electron tunneling spectroscopy without any chemical manipulation or labeling of DNA. We have experimentally validated our method using a scanning tunneling microscope (STM) and have made nanoelectrodes separated by a 2 nm gap for performing the sequencing on a chip.

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Nanotech 2007 Conference Program Abstract


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