2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Biomimetic Nanostructured Interfaces for Enhanced Osseointegration

K.C. Popat and T.A. Desai
University of California, San Francisco, US

biomimetic, nanostructured, osseointegration, osteoblasts

Placement of prosthetic skeletal implants has improved the quality of life for millions of people in the world. It is estimated that over 500,000 total joint replacements, primarily hips and knees, and between 100,000 and 300,000 dental implants are used each year in the United States alone. The success of these implants depends on acquiring and retaining stable fixation of the device at the bony site. A goal of current orthopedic biomaterials research is to design implants that induce controlled, guided, and rapid healing. In order to achieve this, the bone cells should be able to adhere on the surface, differentiate and deposit bone matrix. The cellular response of adhesive cells can be regulated by modifying the surface chemistry or the topography at nanoscale of the substrate. It is well known that by providing the surface nanoarchitecture comparable to that of bone nanostructure improved matrix deposition. Also, it is well known that modification of substrates with proteins and peptides influences cell adhesion as well as differentiation. Thus, in this work we have used nanotubular titania surfaces modified them with various peptides to improve cellular response. We hypothesize that increasing cell adhesion and spreading will promote differentiation of MSCs into osteoblast-like cells under osteogenic conditions.

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Nanotech 2007 Conference Program Abstract


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