2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Hyperhtermia effect of surface-modified magnetite nanoparticles in a microfluid system

C.Y. Lin and K.C. Ho
National Taiwan university, TW

superparamagnetic, magnetite nanoparticles, hyperthermia

Fe3O4 nanoparticles (NPs) was first synthesized via coprecipiatation. After synthesis and purification of the Fe3O4 NPs, poly(acrylic acid) (PAA) was coated on them at specified conditions. The coating process is not possible at pH higher than 5.5 due to the electrostatic repulsion between Fe3O4 NPs and ionized PAA. FTIR of the PAA-coated NPs indicates that the characteristic IR absorption peaks of PAA at 1710, 1405 and 1540 cm 1 are also noticed in the spectrum of PAA-modified NPs. From the X-ray diffraction result, the crystal structure of the surface-modified NPs belongs to standard Fe3O4 crystal. The dispersibility of the SMMNPs was influenced by pH. As pH value becomes larger, the size distribution of the NPs becomes narrower. It was found that the PAA-coated Fe3O4 and Fe3O4 NPs are superparamagnetic. After applying a magnetic field (5 kA/m and 69.44 kHz), the SMMNPs can increase the temperature of the solution in the range of 4.7~ 6.5 °C in 15 min, which is suitable for hyperthermia. To improve the heating effect of the PAA-coated NPs, it is necessary to lower the amount of PAA coating. After coating folic acid and poly-2-oxazoline on these SMMNPs, hyperthermia effect in a microfluidic system will be investigated.

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