2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Lab-on-chip for the isolation and characterization of circulating tumor cells

W. Laureyn, C. Liu, C.K. O’Sullivan, E. Llaudet, O. Nilsson, K.S. Drese, T. Roeser, M. Ritzi, S. Hauch, W. Albert, E. Borgen and A.O.H. Nygren

lab-on-chip, microfluidics, circulating tumor cells

A consortium of 7 European partners has undertaken the challenging task to develop a microfluidic system ( TAS) capable of the isolation/enrichment and consecutive RNA/DNA characterization of circulating tumor cells (CTCs), to be used as a minimally-invasive tool for the early, primary diagnosis of cancer, for cancer therapy monitoring and for the detection of recurrent disease. The lab-on-chip device will integrate three microsystem modules with state-of-the-art microfluidics/microengineering: 1) magneto-electronics based device for the isolation, enrichment and detection of rare cells from complex samples; based on immunomagnetic isolation; 2) multiplexed, micro-scale RNA/DNA amplification on the isolated rare cells, based on Multiplexed Ligand Probe Amplification (MLPA); 3) array of electrochemical biosensors for the consecutive analysis of amplified nucleic acids.

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Nanotech 2007 Conference Program Abstract


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