2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

A Microfluidic Mixer for Chaotic Mixing of Magnetic Particles

M. Zolgharni, S.M. Azimi, M.R. Bahmanyar and W. Balachandran
Brunel University, UK

microfluidic, chaotic mixing, magnetic particles

Magnetic isolation of specific biological entities through utilizing super-paramagnetic micro-particles has been of great interest in both bench-top and microfluidic platforms. Since the magnetic particles and target entities are suspended in separate fluids, prior to separation of the labelled-cell/particle complex from contaminants, magnetic particles must be distributed into the bio-fluid containing target entity through a mixing process. In bench-top protocols, this is done using conventional turbulent mixing techniques. However, in micro-scale devices where Reynolds number is often less than 1, mixing is not a trivial task due to absence of turbulence. While separation of particles in microdevices based on magnetic forces has been reported by different researchers, there are only a few prototypes developed for mixing of particles in microscale. We present a study on chaotic mixing of magnetic particles into a bio-fluid in order to evaluate the efficiency of the mixer in capturing the target cells with particles.

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