2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Development of novel carbon fiber sheet as a scaffold for bone regeneration

N. Narita, Y. Usui, H. Kato, Y.A. Kim, M. Endo and N. Saito
Shinshu University, JP

carbon fiber, BMP, bone regeneration, scaffold

We developed a novel carbon fiber sheet that is useful as a scaffold for bone regeneration. Carbon fibers measuring almost 1µm in diameter are knitted into sheet. Carbon fiber sheets containing rhBMP-2 (0.1 µg, 0.5 µg, 1.0 µg) were transplanted under the muscle membrane on the backs of mice. Collagen sheets were used as controls. After 3 weeks, ectopic bone tissues formed around the sheets were removed. On X-ray photographs, there was no bone formed in the 0.1 µg BMP group, but there was bone formed in the 0.5 and 1.0 µg BMP groups. Specimens stained by hematoxylin and eosin demonstrated that bone matrix had formed around the carbon fibers and that bone marrow existed within the newly formed bone tissue. Bone density and bone volume were increased with the dosage of BMP and larger amounts of tissue were formed around carbon fiber sheets than around collagen sheets. Carbon fiber sheets have potential as drug delivery system for BMP and as a scaffold to treat bone defect.

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