2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Controlled Au-PPy Valves for Drug Delivery Systems

Han-Kuan Anthony Tsai, Lawrence Kulinsky, Marc Madou
University of California, Irvine, US

drug delivery, microfabrication, polypyrrole, BioMEMS

An alternative method for the responsive drug delivery system which includes batteries, sensors, telemetry, valves, and drug storage reservoirs is proposed. Using this device, drug concentration can be precisely controlled which enhances drug efficiency and decreases the side effects. In order to achieve responsive drug delivery, a reliable release device (e.g., a valve) has to be developed. The valves feature a bi-layer structure where one layer is a thin metal film, functions as a structural layer and a working electrode, and the other layer is an electrochemically deposited polypyrrole (PPy) film. The volume change of the polypyrrole film forces the bi-layer to bend resulting in opening and closing of the valve. To prevent the valve being blocked by muscle or tissue, a piece of poly dimethyl siloxane (PDMS) with an array of reservoirs has been molded and sealed on the substrate. The PDMS chip can serve as the package to shield the valve from outside environment and it can also function as the reservoirs to store the therapeutic agents. A parylene coating is applied to decrease the permeability of PDMS. A considerable reduction of moisture vapor transmission rate is achieved by coating parylene on the PDMS surface. It is believed that this novel fabrication approach can be profitably extended to the new generation of the drug delivery devices.

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Nanotech 2007 Conference Program Abstract


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