2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Effect of Vitamin E TPGS on Cyclosporin A loaded PLA microparticles

E. Yeung, C-S Chaw, Y-Y Yang
University of sunderland, UK

Microparticle, TPGS, PLA, spray drying

Purpose. To study the effect of TPGS on cylcosporin A (CyA) loaded poly (lactide) (PLA) microparticles. Methods. Spray dried PLA microparticles were prepared using either ethyl acetate (EA) or dichloromethane (DCM) as solvents. The particles were characterised for morphology, particle size distribution and dissolution rate. The surface properties of microparticles were investigated using XPS and interaction between PLA, CyA and TPGS was studied using DSC. Results. CyA loaded spray dried PLA microparticles possessed particle size ranging between 1-5 m. EA formed microparticles with smooth surface when compared to those produced by DCM. Thermal analysis has shown that TPGS lowered Tg value of PLA while CyA reverted this effect. Increasing TPGS content from 2% (w/w) to 20% (w/w), the microparticles agglomerated due to lowering of polymer Tg values’ below spray dried temperature. XPS analysed has shown that lesser amount of CyA at the surface for these microparticles and has resulted in smaller initial release of CyA. At low content of TPGS, initial release of CyA was increased and particles were not agglomerated. Conclusions. By adjusting amount of TPGS and CyA in the polymer solution to achieve Tg value above spray drying temperature, microparticles show good dispersibility and enhanced CyA dissolution.

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