2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

On-Chip Micro-Flow Injection Analysis with Integrated Dual Monolithic Silica Based Electro-Osmotic Pumps and Ion-Exchange Concentrator Column for the Analysis of Trace Cations

F.Q. Nie, M. Macka and B. Paull
Dublin City University, IE

Micro-FIA, monolith, preconcentration

Here, in an attempt to explore effective routes to improve detection sensitivity in micro-flow injection analysis system ( -FIA), a novel -FIA system based upon a 40×50×2 mm micro-fluidic polymer chip and incorporating on-chip sample preconcentration is presented. The system consists of two integrated but independent electroosmotic pumps (EOPs) for the delivery of the carrier solution and combined sample injection and ion-exchange preconcentration. The -FIA system was based upon encased monolithic silica capillaries working as independent carrier solution and sample injection EOPs capable of generating L/min flow rates and reproducible sample injection at the nL level. Detection was achieved using off-chip on-capillary capacitively coupled contactless conductivity detection.The application of the -FIA system has been demonstrated with a sevenfold increase in peak height and fourfold increase in peak area for a calcium standard solution (10 M) after on-chip preconcentration. Importantly, the consumption of sample to achieve the above improvement in detection sensitivity was only 20 L.

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