2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Nanowire Array Technologies for Investigation of Neural Activity

S. Saha, J. Silverberg, D. Nagesha, S. Sridhar, D. O’Malley and L. Menon
Northeastern University, US

Biorecognition, brain-machine interface, gold, nanoelectrode, nanowire array, neuronal network, peptide

Nanostructures are expected to play a key role in the fundamental investigation of neuronal activity at the nanoscale level. Neurons are complex structures with feature sizes ranging from the millimeter to micron to nanoscale regimes. Single nanowires and/or nanowire arrays can therefore offer the potential to investigate the operations of living neural networks in precise detail, tracking small changes in cell structure and electrical activity in a minimally invasive fashion and at the same time with excellent spatial and temporal resolution. Such studies should thus improve our understanding of brain functions. We report our results on the development of an array of conducting gold nanowires suitably integrated with gold electrodes for the recording of neural activity. Our preliminary results in the development of such a device and the interaction of such nanowire-arrays with cultured mouse neuroblastoma cells and rat hippocampal cells are discussed.

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Nanotech 2007 Conference Program Abstract


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