2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Mutagenicity of Titanium Dioxide Nano-particles

J.Y Yang, J.Y. Jang, E.H. Lim, Y.W. Lim, C.S. Kim, J.W. Chun and D.C. Shin*
Ph.D, KR

titanium dioxide (TiO2), nano-particle, mutagenicity, anatase, rutile

TiO2 is manufactured worldwide in large quantities for use in a wide range of applications. In order to assess the potential toxicity for producing genetic damage, we investigated the mutagenicity of TiO2 (anatase and rutile) in the Salmonella typhimurium reverse mutation assay. TiO2 was mutagenic to Salmonella typhimurium TA98 and TA100 without metabolic activation. 2-Nitrofluorene and titanium ion was used as a positive control. DMSO and Milli-Q ultrapure water was used as a negative control. Although TiO2 nano-particles were assessed as a weak mutagen, titanium ion was assessed as a strong mutagen. There is a possibility that it may give rise to health issues when TiO2 nano-particles change to ions in the human body.

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