2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Drug delivery model using biocompatible nanoparticles

A.G. Lacko, M.P. Nair, S. Paranjape, L. Mooberry, W.J. McConathy

synthetic lipoprotein, drug delivery, targeted nanoparticle

Reconstituted high density lipoprotein particles carrying paclitaxel (rHDL/PTX) were prepared with substantially higher PTX content than reported earlier. .(Anticancer Research 22(4):2045-9[2002]). The rHDL/PTX complexes appeared to be primarily spherical nanoparticles when examined via electron microscopy, with a constant composition, molecular weight and exceptional stability by both ultracentrifugation,and storage up to six months. The rHDL/ PTX nanoparticles had superior cytotoxicity against several cancer cell lines with an IC50 5-20 times lower than that of the free drug. Studies with mice showed that the rHDL/PTX nanoparticles were substantially better tolerated than the corresponding dosages of either Taxol® or Abraxane®

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Nanotech 2007 Conference Program Abstract


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