2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

The Effect of Silicon Nanowires on Hepatocellular Carcinoma: Cytotoxicity & Adhesion Effect

S. Qi, C. Yi, W. Chen, C-C Fong, S-T Lee and M. Yang
City University of Hong Kong, CN

silicon nanowires, HepG2, cytotoxicity, adhesion and spreading

The unique capabilities of nanomaterials make them good candidates for catalysts, biosensors, and even drug carriers. However, interactions of nanomaterials with biological systems and the environment may lead to potential toxicity. While there have been reports on the cytotoxicity of carbon nanotubes, quantum dots, gold nanoparticles, and the biocompatibilities of carbon nanotubes, no study has yet appeared on the biological effects of silicon nanowires, which are becoming increasingly important as a nanomaterial. Silicon nanowires (SiNWs), as a one-dimensional nanomaterial, typically are composed of a single crystalline silicon core and an amorphous SiOx sheath. Their outstanding properties such as quantum size effects, diameter-dependent thermal conductivity and large piezoresistance coefficient have attracted a lot of research interests, including applications as biological materials and devices. However, before SiNWs can be incorporated into new and existing biomedical devices, their cytotoxicity and their potential adverse effects on biological systems should be thoroughly investigated. Herein, we report the first study on the cytotoxicity of SiNWs to HepG2 cells and its effect on cell adhesion and spreading.

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