2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Multivalent magnetic nanoparticles for T cell-specific tracking via magnetic resonance and fluorescence imaging for cancer treatment reporting

J. Gunn, O. Veiseh, C. Sun, C. Fang, H. Wallen, J. Cao, C. Yee and M. Zhang
University of Washington, US

superparamagnetic, iron oxide nanoparticle, t cell

Cell-based cancer therapy has been recently bolstered through the development of new viable techniques such as adoptive T cell therapy. The ability to monitor the movement of specific T cells to cancer lesions provides clinicians with the enhanced ability to tailor these new cancer-treatment plans and optimize cell therapies. By loading active T cells with superparamagnetic nanoparticles, Magnetic Resonance (MR) imaging can be used to visualize cell movement with high spatial and temporal resolution, unmatched by radiolabeled or bioluminescent cells. Furthermore, targeted-nanoparticles will allow the tagging of cells for tracking purposes without external preloading.

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Nanotech 2007 Conference Program Abstract


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