2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

A pbpk model to elucidate processes governing distribution and excretion of polyacrylamide nanoparticles

Y. Wenger, O. Jolliet, R. Schneider and M. Philbert
University of Michigan, US

nanoparticle, polyacrylamide, pharmacokinetics, tissue distribution, physiologically based pharmacokinetic model

This paper presents a physiologically based pharmacokinetics model that has been calibrated using experimental measurements of biodistribution and excretion of polyacrylamide nanoparticles in rats. The model is capable of establishing the complete mass balance of nanoparticles, including blood content, excretion, and different locations of accumulation (Organs of the RES, peripheral tissues). It explores the basis for scaling and identify key factors affecting the pharmacokinetics of nanoparticles.

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Nanotech 2007 Conference Program Abstract


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