2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Simulation on biological cell transport in the microfluidic devices

M.C. Kim, Z.H. Wang, R.H.W. Lam and T. Thorsen
Massachusetts Institute of Technology, US

cell, trajectory, microfluidics, simulation

We have developed a Bio-Particle (BP) simulation technique for the general particle movement in Lab-On-A-Chip devices. This has also been validated with experiments on biological cells (3T3 cell; diameter 10 m). The cell motion under steady flow was calculated by applying the one-way coupled Lagrangian method. Each cell was assumed to be a solid sphere with adjustable elasticity, while the physical interactions between cells and device structures were also considered, particularly when cells sediment in the U-type sieve structures. The BP technique was further applied in the performance analysis of three types of cell trapping structures: C-shaped, Flat-type and U-type sieves. By locating sieves with different configurations in a microchamber (400 m diameter), the number of cells trapped can be estimated by simulation. Our simulation predicted that the U-type sieves would obtain an even distribution and a more consistent saturated cell population. Experiments indicate a good agreement with such prediction. The experiments were conducted by seeding biological cells along a microfluidic channel containing multiple cell-trapping chambers. Thereby, the BP technique was successfully applied to obtain an optimized structure of the sieve-type cell trapping chamber.

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