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Novel Photonic Technique Creates Micrometer Resolution Multi-sensor Arrays and Provides a New Approach to Coupling of Genes, Nucleic Acids, Peptide Hormones and Drugs to Nanoparticle Carriers

M.T. Neves-Petersen, M. Duroux, L. Duroux, E. Skovsen and S.B. Petersen
Professor, DK

biosensor, protein immobilisation, microarray, drug delivery, nanoparticles

Photonic induced immobilisation is a novel patented technology resulting in spatially oriented and localised covalent coupling of biomolecules onto surfaces. Immobilisation has been achieved for a wide selection of proteins, e.g., human plasminogen, alkaline phosphatase, immunoglobulins’ Fab fragment, Major Histocompability Complex Class I protein. The reported new technology involves light induced breakage of disulphide bridges in proteins upon UV illumination of nearby aromatic amino acids, resulting in the formation of free, reactive thiol groups that will form covalent bonds with thiol reactive surfaces. The presented technology is ideal to create highly dense protein multisensor microarrays. We hereby present the fluorescent labelled PSA (Prostate specific antigen) and cutinase microarray. Interestingly our studies show that this technology bypasses the use of microdispensors broadly applied in microarray technology since the spatial resolution of this technique will be defined by the area of the sensor surface that is illuminated and not by the physical size of the dispensed droplets of sensor molecules. This technology is ideal to couple drugs to e.g., gold nanoparticles which can be used as molecular carriers into cells for therapeutical purposes. Recent data has shown that the same approach may be used for therapeutical purposes in human cancer (patent submitted).

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