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Wettability Engineering and Bioactivation of Hydroxyapatite Nanoceramics

G. Rosenman and D. Aronov
Tel Aviv University, IL

wettability engineering, bioactivation, patterning, cells adhesion

The major trends in biotechnology and tissue engineering are development of materials with controlled surface substrates. One of the critical factors influencing adhesion of biocells is wettability properties of the biomimetic substrates. Hydrophilicity (hydrophobicity) of any solid state surface depends on interfacial physical properties which can be varied by topographic nanostructuring, surface chemical modification and external electric field
Another option to modify the wettability and bioactivity is generation of electric field by modification of the surface charge of the semiconductor (dielectric) material. We report about new method enabling reversible switching or gradual transition of wettability properties of solid state surfaces by surface potential modulation1. The latter is varied by low energy electron irradiation. Combination of applied in this work various methods allowed to study electron energy states spectrum of Hydroxyapatite nanoceramics. It is found that wettability of the Hydroxyapatite maybe varied in a wide range characterized by contact angles 10-110. The experimental data on wettability engineering and wettability patterning, characterization and variation of wettability properties of human implants, adhesion of biological cells of different origin on Hydroxyapatite bionanoceramics are presented2.
1 G. Rosenman, D. Aronov, Provisional Patent (2005)
2 G. Rosenman, D. Aronov, Appl. Phys. Lett., (2005, submit)

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