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Direct-Write CMOS-Based Laboratory-On-Chip

E. Ghafar-Zadeh, M. Sawan and D. Therriault
École Polytechnique de Montréal, CA

lab-on-chip, direct-write, CMOS, microfluidic

Over the recent years, the identification of genes which influence many diseases has been highly demanded and now, molecular diagnosis is most promising technology to offer fast and early detection of diseases to a maximum number of people.Up to now, most efforts of low cost and high precision microfabrication technology have been devoted to conventional genetic assay protocols [ ] for the DNA analysis and expression analysis which results in advanced and easy-to-use commercial products like GeneChip@Mapping 500K Array Set, enabling researcher to hybridize the prepared sample after extracting, amplifying, and labeling nucleic acids from experimental samples. The time-consuming and expensive sample preparation from a raw sample is unsuitable for many applications like continuous monitoring and point-of-care where less attempts has been made to automate and miniaturize the traditional process on raw sample.the potential of dielectrophoresis in cell preparation and analysis and also its Integration with Lab-on-chip (LOC) systems has been exploiting sucessfully in publications. there is one challenging issue: full electronic detection in CMOS has only a few handred micrometer or less area, where usual microfluidics need a few hundred milimiter or more------>>>> we presented a hybrid (CMOS+Microfluidic) system based on direct-wrire microfluidic fabrication technique which has many application in cell prepration, flow cytometry, cell seperation and detection,..

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