Nanotechnology Conference and Trade Show - Nanotech 2006
> Program > Technical Conferences > Business & Development > Nano Impact Workshop > Nanotech Job Fair > Expo
Index of Authors
Index of Keywords
Confirmed Speakers
Conferences & Symposia

Conference Proceedings

Conference Technical Proceedings

Nanoparticulate Drug Delivery Systems for the Non-Invasive Chemotherapy of Brain Tumors

S. Gelperina
Russian Research Center of Molecular Diagnostics and Therapy, RU

Cancer, therapy, drug delivery, nanoparticles, non invasive

Effectiveness of the chemotherapy of brain pathologies is often impeded by insufficient drug delivery across the blood-brain barrier (BBB).  The routine approaches applied for the enhancement of drug concentrations in the brain are highly invasive. One of the attractive and innovative alternatives is the non-invasive systemic drug delivery to the brain by means of the nanoparticles.  The authors of the technology provided the experimental evidence that poly(butyl cyanoacrylate) nanoparticles coated with polysorbate 80 enabled efficient brain delivery of the antitumor antibiotic doxorubicin, which is unable to cross the BBB in a free form. Evaluation of the therapeutic potential of this formulation in rats with intracranial glioblastoma demonstrated its high efficacy: the nanoparticle-bound doxorubicin was able to produce long-term remission in >20% animals, whereas in the control group all animals died within 20 days. The surviving animals were euthanized after 3 months and showed no signs of tumor growth at necropsy. The toxicological studies of the nanoparticle-bound doxorubicin provided evidence that this formulation is characterized by a significantly improved toxicological profile, being considerably less toxic for heart and testes. Further studies demonstrated that this technology could be extended to the nanoparticles made of commercially available pharmaceutical polymers, such as poly(lactide-co-glycolide). These important and potentially highly useful results may open up totally novel possibilities for the treatment of diseases of the central nervous system including brain tumors, meningitis of various etiology, Alzheimer's, Parkinson, cerebral AIDS, and other neurological diseases. The technology is patented.

Back to Program

Sessions Sunday Monday Tuesday Wednesday Thursday Authors

Nanotech 2006 Conference Program Abstract

Nanotechnology Conference | Terms of use | Privacy policy | Contact | NSTI Home
Program | Technical Conferences | Business & Development | Nano Impact Workshop | Nanotech Job Fair | Expo |
Nanotech 2006 Home | Press Room | Venue | Subscribe | Site Map
Names, and logos of other organizations are the property of those organizations and not of NSTI.
This event is not open to the general public and NSTI reserves the right to refuse admission and participation to any individual.