Nanotechnology Conference and Trade Show - Nanotech 2006
> Program > Technical Conferences > Business & Development > Nano Impact Workshop > Nanotech Job Fair > Expo
Index of Authors
Index of Keywords
Confirmed Speakers
Conferences & Symposia

Conference Proceedings

Conference Technical Proceedings

Use of Multi-Criteria Decision Analysis Tools to Facilitate Weight-of-Evidence Evaluation in Nanotechnology Risk Assessment

I. Linkov, K. Satterstrom, S. Zemba, J. Steevens
Cambridge Environmental Inc., US

nanoparticles, toxicology, weight of evidence, decision support

Elucidation of nanomaterial toxicity requires multiple sets of information due to both the complexity of nanomaterials and the limited database of relevant experimental studies. The EPA and other agencies use a weight-of-evidence approach in evaluating the potential carcinogenicity and toxicity of environmental contaminants. Traditionally, assessors weigh various lines of evidence and apply professional judgment and/or calculations to decide where the weight of evidence lies – that is, whether the various lines of evidence point to potential risk in the case of each receptor or not. Even though weight-of-evidence considerations may use some quantification, this approach often results in arbitrary weight selection (e.g., conservative bias) and thus in risk estimates that include an unquantified degree of uncertainty and potential bias. We argue that weight-of-evidence approaches may be useful for assessing the toxicity of nanomaterials, but a limited knowledge base and high uncertainty and variability in their basic properties requires coupling traditional weight-of-evidence assessments with multi-criteria decision analysis (MCDA) to support toxicity assessment and regulatory decision making. MCDA offers a rigorous and consistent approach. Even though MCDA is often used to incorporate social factors into decision making processes, this presentation will illustrate the potential of MCDA to facilitate purely technical evaluation of the multiple lines of evidence used in typical human health risk assessment for nanomaterials.

Back to Program

Sessions Sunday Monday Tuesday Wednesday Thursday Authors

Nanotech 2006 Conference Program Abstract

Nanotechnology Conference | Terms of use | Privacy policy | Contact | NSTI Home
Program | Technical Conferences | Business & Development | Nano Impact Workshop | Nanotech Job Fair | Expo |
Nanotech 2006 Home | Press Room | Venue | Subscribe | Site Map
Names, and logos of other organizations are the property of those organizations and not of NSTI.
This event is not open to the general public and NSTI reserves the right to refuse admission and participation to any individual.